Infection and Alzheimer's Disease: The APOE ε4 Connection and Lipid Metabolism
作者： Nadezda Urosevic , Ralph N. Martins
关键词:
摘要: Microorganisms, bacteria and viruses may infect cause a range of acute chronic diseases in humans dependent on the genetic background, age, sex, immune health status host, as well nature, virulence dose infectious agent. Late onset Alzheimer's disease (AD) is progressive neurodegenerative illness broad aetiology with strong component significant contribution sex life style factors. Both AD are characterised by an increased production array mediators, cytokines, chemokines complement proteins host cells changes lipid metabolism. In this review, we re-examine dangerous liaison between several viral bacterial infections most factor for AD, APOE epsilon4, possible impact alliance development. This connection was discussed broader context metabolism light different capacity various agents, their toxic lipophilic products lipoprotein particles binding to cell receptor(s).
medra.org 参考文章(137)
Mary Lou Lewis, William W. Culbertson, M. Judith D. Post, Darlene Miller, Gregg T. Kokame, Richard D. Dix, Herpes Simplex Virus Type 1: A Cause of the Acute Retinal Necrosis Syndrome+ Ophthalmology. ,vol. 96, pp. 875- 878 ,(1989) , 10.1016/S0161-6420(89)32823-5
Hayyoung Lee, Hak Chul Hyun, Young Sang Kim, Jong Dae Park, Hyung Ok Sohn, Dong Wook Lee, Han Jae Shin, Kinetics of binding of LPS to recombinant CD14, TLR4, and MD-2 proteins. Molecules and Cells. ,vol. 24, pp. 119- 124 ,(2007)
J Moldvay, P Deny, S Pol, C Brechot, E Lamas, Detection of hepatitis C virus RNA in peripheral blood mononuclear cells of infected patients by in situ hybridization Blood. ,vol. 83, pp. 269- 273 ,(1994) , 10.1182/BLOOD.V83.1.269.269
Gundo Diedrich, How does hepatitis C virus enter cells FEBS Journal. ,vol. 273, pp. 3871- 3885 ,(2006) , 10.1111/J.1742-4658.2006.05379.X
Carl Grunfeld, Kenneth R. Feingold, The role of the cytokines, interferon alpha and tumor necrosis factor in the hypertriglyceridemia and wasting of AIDs Journal of Nutrition. ,vol. 122, pp. 749- 753 ,(1992) , 10.1093/JN/122.SUPPL_3.749
E. Hone, I.J. Martins, M. Jeoung, T.H. Ji, S.E. Gandy, R.N. Martins, Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding. Journal of Alzheimer's Disease. ,vol. 7, pp. 303- 314 ,(2005) , 10.3233/JAD-2005-7406
E. Hone, I.J. Martins, J. Fonte, R.N. Martins, Apolipoprotein E influences amyloid-beta clearance from the murine periphery Journal of Alzheimer's Disease. ,vol. 5, pp. 1- 8 ,(2003) , 10.3233/JAD-2003-5101
Tony Wyss-Coray, Tony Wyss-Coray, Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nature Medicine. ,vol. 12, pp. 1005- 1015 ,(2006) , 10.1038/NM1484
C. Zeng, J. T. Lee, H. Chen, S. Chen, C. Y. Hsu, J. Xu, Amyloid‐β peptide enhances tumor necrosis factor‐α‐induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes Journal of Neurochemistry. ,vol. 94, pp. 703- 712 ,(2005) , 10.1111/J.1471-4159.2005.03217.X
Qiao Yan, Jianhua Zhang, Hantao Liu, Safura Babu-Khan, Robert Vassar, Anja Leona Biere, Martin Citron, Gary Landreth, Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease The Journal of Neuroscience. ,vol. 23, pp. 7504- 7509 ,(2003) , 10.1523/JNEUROSCI.23-20-07504.2003