Palliative thoracic radiotherapy for non-small-cell lung cancer: a systematic review.
作者： Elizabeth Toy , Fergus Macbeth , Bernadette Coles , Arabella Melville , Alison Eastwood
DOI: 10.1097/00000421-200304000-00002
关键词:
摘要: Non-small-cell lung cancer is one of the most common malignant tumors worldwide. The majority patients are not treatable with curative intent because extent disease or patient comorbidity. Radiotherapy to primary intrathoracic tumor used aim palliating troublesome local symptoms in approximately 25% patients. dose/fractionation regimens evolved empirically, and surveys have shown widespread variation. It has yet been clearly established which give benefit least toxicity. This systematic review identified 12 randomized controlled trials comparing palliative external beam radiotherapy regimens. Narrative synthesis performed. Palliative effective controlling symptoms. There no strong evidence that better palliation obtained higher radiation doses but good toxicity greater. a modest survival dose schedules performance status. should receive short courses (one two fractions) hypofractionated radiotherapy, Selected status be considered for if chance improvement worth additional inconvenience
sci-hub.se 参考文章(30)
RJ Stephens, P Hopwood, DJ Girling, D Machin, Randomized trials with quality of life endpoints: are doctors' ratings of patients' physical symptoms interchangeable with patients' self-ratings? Quality of Life Research. ,vol. 6, pp. 225- ,(1997) , 10.1023/A:1026458604826
John F. Fowler, The linear-quadratic formula and progress in fractionated radiotherapy British Journal of Radiology. ,vol. 62, pp. 679- 694 ,(1989) , 10.1259/0007-1285-62-740-679
Timothy E. Schultheiss, L. Clifton Stephens, Permanent radiation myelopathy British Journal of Radiology. ,vol. 65, pp. 737- 753 ,(1992) , 10.1259/0007-1285-65-777-737
JM Singer, P Price, RG Dale, Radiobiological prediction of normal tissue toxicities and tumour response in the radiotherapy of advanced non-small-cell lung cancer. British Journal of Cancer. ,vol. 78, pp. 1629- 1633 ,(1998) , 10.1038/BJC.1998.734
Ming Chen, Guo-Liang Jiang, Xiao-Long Fu, Li-Juan Wang, Hao Qian, Gui-Yuan Chen, Sen Zhao, Tai-Fu Liu, The impact of overall treatment time on outcomes in radiation therapy for non-small cell lung cancer. Lung Cancer. ,vol. 28, pp. 11- 19 ,(2000) , 10.1016/S0169-5002(99)00113-0
Matthew Q.F. Hatton, Desni L. Nixon, Fergus R. MacBeth, R.Paul Symonds, Acute changes in peak expiratory flow rate following palliative radiotherapy for bronchial carcinoma Radiotherapy and Oncology. ,vol. 44, pp. 31- 34 ,(1997) , 10.1016/S0167-8140(96)01892-0
G.J.G. Rees, C.E. Devrell, V.L. Barley, H.F.V. Newman, Palliative radiotherapy for lung cancer: two versus five fractions. Clinical Oncology. ,vol. 9, pp. 90- 95 ,(1993) , 10.1016/S0936-6555(05)80446-7
P Dixon, M Brundage, M Palmer, B Zee, J Peter, C Leong, L Mulroy, J Wright, C Grafton, P Blood, C Lochrin, Characteristics of lung cancer patients entered on a Canadian palliative radiotherapy study (National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) SC.15 study) Lung Cancer. ,vol. 29, pp. 171- ,(2000) , 10.1016/S0169-5002(00)80578-4
F MACBETH, J BOLGER, P HOPWOOD, N BLEEHEN, J CARTMELL, D GIRLING, D MACHIN, R STEPHENS, A BAILEY, Randomized trial of palliative two-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small cell lung cancer and good performance status Clinical Oncology. ,vol. 8, pp. 167- 175 ,(1996) , 10.1016/S0936-6555(96)80041-0
E.J. Maher, L. Coia, G. Duncan, P.A. Lawton, Treatment strategies in advanced and metastatic cancer: differences in attitude between the USA, Canada and Europe. International Journal of Radiation Oncology Biology Physics. ,vol. 23, pp. 239- 244 ,(1992) , 10.1016/0360-3016(92)90568-3