Statistical and Computational Studies on Alternative Splicing

摘要: The accumulating genome sequences and other high-throughput data have shed light on the extent importance of alternative splicing in functional regulation. Alternative dramatically increases transcriptome proteome diversity higher organisms by producing multiple splice variants from different combinations exons. It has an important role many biological processes including nervous system development programmed cell death. Many human diseases cancer arise defects its This chapter reviews statistical computational methods genome-wide studies.