Cholesterol modified amphiphilic pH response pennicuius copolymer as well as preparation and micelle of copolymer
作者： Zhao Bin , Yao Na , Lin Wenjing , Zhang Lijuan , Zhang Canyang
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摘要: The invention belongs to the technical field of preparation biomedical high molecular polymer materials and discloses a cholesterol modified amphiphilic pH response pennicuius copolymer method micelle system prepared based thereof. has structure shown in formula I specification, wherein x is 10-36, y 15-40 z 8-30. obtained by virtue irregular copolymerization hydrophilic block hydroxyethyl methylacrylate, hydrophobic methacrylic acid N, N-diethyl aminoethyl combined with poly(ethylene glycol) methyl ether methacrylate. dissolved solvent obtain nanoscale system, inner layer chain segment, middle segment shell so that function entrapment performance, stable existence neutral condition quick release weak acidic achieved. By adjusting proportions blocks polymer, rates medicines can be regulated satisfy requirements on different drugs.
lens.org 参考文章(2)
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