Partial Surgical Removal of Growth Hormone-Secreting Pituitary Tumors Enhances the Response to Somatostatin Analogs in Acromegaly
作者： Annamaria Colao , Roberto Attanasio , Rosario Pivonello , Paolo Cappabianca , Luigi M Cavallo
DOI: 10.1210/JC.2005-1208
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摘要: Context: Surgery is a cornerstone in the treatment of acromegaly, but its efficacy large, invasive tumors scant. Objective: The objective this study was to investigate whether partial surgical removal GH-secreting pituitary enhances response rate somatostatin analogs (SSA; sc octreotide, slow-release and lanreotide). Design: This multicenter, open, retrospective study. Setting: performed at university hospitals. Subjects Methods: Eighty-six patients (42 women 44 men; age, 42 ± 14 yr) with acromegaly were studied. Interventions: Patients underwent two courses lanreotide, or octreotide treatments before after surgery least 6 months. Main Outcome Measure: main outcome measure normal IGF-I levels for age. Results: Presurgical SSA significantly decreased GH all patients. less than 2.5 μg/liter 12 (14%); normalized nine (10%). Af...
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