Low-cost three-dimensional imaging system combining fluorescence and ultrasound.
作者： Baoqiang Li , Maxime Abran , Carl Matteau-Pelletier , Léonie Rouleau , Tina Lam
DOI: 10.1117/1.3662455
关键词:
摘要: In this paper, we present a dual-modality imaging system combining three-dimensional (3D) continuous-wave transillumination fluorescence tomography with 3D ultrasound (US) imaging. We validated the two phantoms, one containing fluorescent inclusions (Cy5.5) at different depths, and another varying-thickness semicylindrical phantom. Using raster scanning, combined fluorescence/US was used to collect boundary emission in X-Y plane, as well recovered surface position of from US signals. images were segmented provide soft priors for image reconstruction. Phantom results demonstrated that derived images, reconstruction quality significantly improved. As further evaluation, show pilot vivo using an Apo-E mouse assess feasibility performance animal studies. Limitations potential be artherosclerosis studies are then discussed.
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