Effect of sleep on swallowing, esophageal peristalsis, and acid clearance.

摘要: Recent studies have shown that impaired esophageal clearance of refluxed material during the sleeping interval plays a major role in pathogenesis esophagitis. The present investigation compares responses to both acid and water infusions sleep asymptomatic subjects. Fourteen healthy individuals were studied. subjects studied for two nights laboratory. Each night involved four six 15 ml either sterile or 0.1 N HCl. A similar infusion was conducted presleep waking interval. Acid time decrease as function increasing wakefulness clearing Arousal significantly greater with (p less than 0.05). Awakenings from associated swallowing rates those 0.01). Peristaltic parameters amplitude, velocity, duration not differentially affected by versus waking.