Evaluation of Urine Choline Levels in Women With and Without Overactive Bladder Syndrome.

摘要: OBJECTIVE The objective of this study was to determine whether levels choline (Ch) differ in women with and without overactive bladder (OAB) symptoms. METHODS New patients were evaluated using the symptom score; Medical, Epidemiologic, Social Aspects Aging (MESA) urgency incontinence questionnaire; Impact Questionnaire 7 provided a urine sample. Patients stratified into asymptomatic controls, scoring 0 on score MESA questionnaire, OAB (OAB-wet). conditions predisposing or had history treatment excluded. Choline detection accomplished commercially available kit. Wilcoxon rank sum test Fisher exact used express differences between groups. Spearman ρ correlation relationship Ch questionnaire scores. Logistic regression identify significant variables associated OAB. RESULTS Sixty-three included final analysis. OAB-wet older (P = 0.001), more likely be obese 0.04), greater apical descent 0.02), postmenopausal 0.01), have stress 0.005). 34.8% lower compared controls 0.014). Lower higher (Spearman -0.311, P 0.03). After logistic regression, (adjusted odds ratio [aOR], 0.97; 95% confidence interval [CI], 0.96-0.98), age (aOR, 1.12; CI, 1.08-1.18), body mass index 1.09; 1.01-1.18) significantly OAB-wet. CONCLUSIONS are decreased complaining incontinence,