Efficacy and Safety of a 4-Factor Prothrombin Complex Concentrate in Patients on Vitamin K Antagonists Presenting With Major Bleeding

作者: Ravi Sarode , Truman J. Milling , Majed A. Refaai , Antoinette Mangione , Astrid Schneider

DOI: 10.1161/CIRCULATIONAHA.113.002283

关键词:

摘要: Background—Patients experiencing major bleeding while taking vitamin K antagonists require rapid antagonist reversal. We performed a prospective clinical trial to compare nonactivated 4-f...

参考文章(43)
Michael Kalina, Glen Tinkoff, Adebayo Gbadebo, Paula Veneri, Gerard Fulda, A protocol for the rapid normalization of INR in trauma patients with intracranial hemorrhage on prescribed warfarin therapy. American Surgeon. ,vol. 74, pp. 858- 861 ,(2008) , 10.1177/000313480807400919
Mike Makris, Mike Greaves, Wendy S Phillips, Steve Kitchen, Frits R Rosendaal, F Eric Preston, Emergency Oral Anticoagulant Reversal: The Relative Efficacy of Infusions of Fresh Frozen Plasma and Clotting Factor Concentrate on Correction of the Coagulopathy Thrombosis and Haemostasis. ,vol. 77, pp. 477- 480 ,(1997) , 10.1055/S-0038-1655992
A Shapiro, M Manco-Johnson, G rd White, EM Gordon, GL Bray, E Scheibel, S Courter, ED Gomperts, M Lee, R Gruppo, A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood. ,vol. 83, pp. 2428- 2435 ,(1994) , 10.1182/BLOOD.V83.9.2428.BLOODJOURNAL8392428
Mohammad Hassan Murad, James R. Stubbs, Manish J. Gandhi, Amy T. Wang, Anu Paul, Patricia J. Erwin, Victor M. Montori, John D. Roback, The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis Transfusion. ,vol. 50, pp. 1370- 1383 ,(2010) , 10.1111/J.1537-2995.2010.02630.X
M. L. VANG, A. M. HVAS, H. B. RAVN, Urgent reversal of vitamin K antagonist therapy. Acta Anaesthesiologica Scandinavica. ,vol. 55, pp. 507- 516 ,(2011) , 10.1111/J.1399-6576.2011.02414.X
Chiara Marchesi, Matteo Pierfranceschi, Mark Crowther, David Garcia, Elaine Hylek, Daniel Witt, Nathan Clark, Alessandro Squizzato, Davide Imberti, Walter Ageno, Francesco Dentali, Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists Thrombosis and Haemostasis. ,vol. 106, pp. 429- 438 ,(2011) , 10.1160/TH11-01-0052
Lesley J. Scott, Prothrombin complex concentrate (Beriplex P/N). Drugs. ,vol. 69, pp. 1977- 1984 ,(2009) , 10.2165/11203690-000000000-00000
Nadine Shehab, Laurence S. Sperling, Scott R. Kegler, Daniel S. Budnitz, National Estimates of Emergency Department Visits for Hemorrhage-Related Adverse Events From Clopidogrel Plus Aspirin and From Warfarin JAMA Internal Medicine. ,vol. 170, pp. 1926- 1933 ,(2010) , 10.1001/ARCHINTERNMED.2010.407
Nicholas M. Boulis, Miroslav P. Bobek, Alvin Schmaier, Julian T. Hoff, Use of factor IX complex in warfarin-related intracranial hemorrhage. Neurosurgery. ,vol. 45, pp. 1113- 1119 ,(1999) , 10.1097/00006123-199911000-00020