Imaging the Aging Brain: Study Design and Baseline Findings of the SENIOR Cohort

摘要: Current demographic trends point towards an aging society entailing increasing occurrence and burden of neurodegenerative diseases. In this context, understanding physiological its turning into neurodegeneration is essential for the development possible biomarkers future therapeutics brain disease. The SENIOR study represents a longitudinal, observational including cognitively healthy elderlies aged between 50 70 years old at time inclusion, being followed annually over 10 years. Our multimodal protocol includes structural, diffusion, functional, sodium magnetic resonance imaging (MRI) 3 T 7 T, positron emission tomography (PET), blood samples, genetics, audiometry, neuropsychological neurological examinations as well assessment neuronal risk factors. One hundred forty-two participants (50% females) were enrolled in cohort with mean age 60 (SD 6.3) years baseline. Baseline results multiple regression analyses reveal that cerebral white matter lesions can be predicted by cardiovascular cognitive factors age. Cardiovascular strongly associated juxtacortical periventricular lesions. Intra-subject across-test variability measure test performance marker predicts volume significantly profile. Division subjects higher lower profile shows significant differences intra-subject volumes cortical thickness regions temporal lobe. There no difference lower- higher-risk groups amyloid load using PET data from subset 81 subjects. We here describe baseline findings which aim establishment integrated, multiparametric maps normal identification early neurodegeneration. show age, gender, combined influence decline represented decrease volume, thickness, increase will used underlying basis further implications degeneration examination under different aspects pathology versus aging.