Palladium-catalyzed asymmetric benzylation of 3-aryl oxindoles.
作者： Barry M. Trost , Lara C. Czabaniuk
DOI: 10.1021/JA1079755
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摘要: Herein we report palladium-catalyzed asymmetric benzylic alkylation with 3-aryl oxindoles as prochiral nucleophiles. Proceeding analogously to allylic alkylation, benzylation occurs in high yield and enantioselectivity for a variety of unprotected methyl carbonates using chiral bisphosphine ligands. This methodology represents novel carbon-carbon bond formation between benzyl group nucleophile generate quaternary center.
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