T Cell Protein Tyrosine Phosphatase in Osteoimmunology.
作者： Xin Xu , Tingting Jia , Dongjiao Zhang , Ya-Nan Wang , Wenjing Zhang
DOI: 10.3389/FIMMU.2021.620333
关键词:
摘要: Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine non-receptor 2 (PTPN2), is an intracellular (PTP) essential in regulating responses metabolism via dephosphorylating target proteins. Tcptp knockout systemic or specific cells can seriously damage function, resulting disorders. This review provided fresh insights into potential role of TCPTP osteoimmunology. Overall, regulation osteoimmunology by extremely complicated. negatively regulates macrophages activation inflammatory factors secretion to inhibit resorption. lymphocytes differentiation lymphocytes-related cytokines signaling maintain homeostasis. expected regulate targeting B under certain time conditions. offers a comprehensive update on roles osteoimmunology, which be promising for prevention treatment loss.
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