Pharmaceutical formulation of duloxetine hydrochloride

作者: Natalija Zajc , Anamarija Vajs , Renata Jakse , Rok Zupet , Anton Stimac

DOI:

关键词:

摘要: The present invention relates to polymorphic forms of duloxetine hydrochloride, especially (duloxetine HCl), which are characterized by an X-ray diffraction pattern with peaks (2θ):9.6, 13.9, 18.0, 18.8, 19.2, 20.8, 27.4, 27.9 (designated form A) or characteristic (2θ): 12.0, 14.8, 19.8, 21.3, 21.6, 22.1, 22.4, 23.1, 24.1 T). also pertains processes for the preparation A and T, involves dissolving hydrochloride in particular solvents cooling solution obtain crystals, that dried.

参考文章(6)
Rajendra Narayanrao Kankan, Pathi L. Srinivas, Puppala Ravikumar, Dharmaraj Ramachandra Rao, Crystalline forms of duloxetine free base ,(2005)
Neil Robert Anderson, Toshihiro Ogura, Toshiro Fujii, Peter Lloyd Oren, Duloxetine enteric pellets ,(1995)
Joseph Herman Krushinski, David Wayne Robertson, David Taiwai Wong, 3-aryloxy-3-substituted propanamines ,(1987)
Patrick J. Jansen, Peter L. Oren, Craig A. Kemp, Steven R. Maple, Steven W. Baertschi, Characterization of Impurities Formed by Interaction of Duloxetine HCl with Enteric Polymers Hydroxypropyl Methylcellulose Acetate Succinate and Hydroxypropyl Methylcellulose Phthalate Journal of Pharmaceutical Sciences. ,vol. 87, pp. 81- 85 ,(1998) , 10.1021/JS970133R
Bandi Parthasaradhi Reddy, Dasari Muralidhara Reddy, Rapolu Raji Reddy, Kura Rathnakar Reddy, Amorphous duloxetine hydrochloride ,(2003)