Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
作者： Lei Zhou , WeiWei Sheng , Chao Jia , Xiaoyang Shi , Rongxian Cao
DOI: 10.1111/JCMM.15676
关键词:
摘要: Our previous studies found overexpression of Musashi2 (MSI2) conduced to the progression and chemoresistance pancreatic cancer (PC) by negative regulation Numb wild type p53 (wtp53). Now, we further investigated novel signalling involved with MSI2 in PC. We identified inositol-3-phosphate synthase 1 (ISYNA1) as a tumour suppressor regulated MSI2. High low ISYNA1 expression were prevalently observed 91 PC tissues. was negatively correlated expression, T stage, vascular permeation poor prognosis patients. What's more, patients expressed high level had significant worse prognosis. And wtp53 Capan-2 SW1990 cells, downregulated silencing. silencing promoted cell proliferation cycle inhibiting p21 enhanced migration invasion upregulating ZEB-1. However, upregulated but ZEB-1, which can be rescued Moreover, reduction resulting from significantly reversed In summary, facilitates development through ISYNA1-p21/ZEB-1 pathway, provides new gene target therapy for
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