Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies.

摘要: We reviewed 107 blood flow activation studies carried out with positron emission tomography and published between January 1993 November 1996. These had reported their findings as peaks of significant difference in cerebral blood-flow (CBF) two scans/tasks located the standardized stereotaxic space. coded each task along several dimensions, including type rate input output, types cognitive processes, relative difficulty tasks within a study. Based on this coding, score (A-B) was calculated for subtraction. Subsequently, frequency distributions scores subtractions yielding peak anterior cingulate region (cingulate peak) were compared those obtained from without (no cingulate-peak). The (n = 158) differed no 229) terms level (p 0.001) presence remote memory component 0.01). Regional differences distribution certain parameters, such level, recent use hand responding, also observed when found cortex (ACC) further classified rostral vs caudal ACC, supracallosal subcallosal limbic paralimbic parts ACC. conclude that plays major role modulating response possibly interacting other parameters nature demands.