Cutaneous pathology in Wegener's granulomatosis. A clinicopathologic study of 75 biopsies in 46 patients.

摘要: While no cutaneous lesion is specific for Wegener's granulomatosis (WG), several histopathologic entities, including leukocytoclastic vasculitis and necrotizing granulomatous inflammation, are characteristic. This report details the features of 75 biopsies from 46 patients with WG. Biopsies were subdivided into histologic groups that included (31%), inflammation (GI) (19%), nonspecific ulceration (4%), superficial dermal epidermal necrosis without (2.7%), erythema nodosum granuloma annulare (1%), chronic acute inflammatory lesions (9%). No convincing example was observed. The subgroups correlated clinical features, results compared those a control group 82 WG skin involvement. We found different courses. Patients developed at an earlier age (median age, 30 years) than did 45 years). Leukocytoclastic shortly after onset (median, 15 months vs. 35 inflammation). All occurred during active disease. Active disease associated mean erythrocyte sedimentation rate twice in same patient when absent. had more rapidly progressive widespread or lesions. A marked excess joint musculoskeletal symptoms renal seen vasculitis. also early group. Cutaneous presentation 12 months). Only 64% These frequently neither nor pulmonary manifestations WG, their progressed slower findings suggest characteristic may correlate activity, distribution, course