Methylation in Malignant Astrocytomas
作者： María del Mar Inda , Juan A. Rey , Xing Fan , Javier S. Castresana
DOI: 10.1007/978-94-007-2019-0_1
关键词:
摘要: The term epigenetics is used to describe the study of stable and heritable alterations in gene expression potential that arise during development cell proliferation. Two epigenetic mechanisms have been thoroughly investigated past few years: DNA methylation histone modifications. failure maintenance these marks can lead inappropriate activation or inactivation signaling pathways result disease, such as cancer. Promoters tumor suppressor genes assessed for hypermethylation with a variety techniques, both at specific loci genome wide. Methylation MGMT gene, which favors treatment results temozolomide, clear example influence astrocytomas. At clinical level, emphasis now on combining inhibitors methyl transferases deacetylases.
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Stephen B. Baylln, James G. Herman, Jeremy R. Graff, Paula M. Vertino, Jean-Pierre Issa, ALTERATIONS IN DNA METHYLATION : A FUNDAMENTAL ASPECT OF NEOPLASIA Advances in Cancer Research. ,vol. 72, pp. 141- 196 ,(1998) , 10.1016/S0065-230X(08)60702-2
Pilar Gonzalez-Gomez, Dolores Arjona, Alberto Isla, M. Eva Alonso, Jesus Lomas, Jose M. De Campos, M. Josefa Bello, Jesus Vaquero, Juan A. Rey, Manuel Gutierrez, Promoter hypermethylation of multiple genes in astrocytic gliomas. International Journal of Oncology. ,vol. 22, pp. 601- 608 ,(2003) , 10.3892/IJO.22.3.601
Helmut Gernsheim, W. H. Fox Talbot and the history of photography Endeavour. ,vol. 1, pp. 18- 22 ,(1977) , 10.1016/0160-9327(77)90005-9
Annegret Kunitz, Marietta Wolter, Jörg van den Boom, Jörg Felsberg, Björn Tews, Meinhard Hahn, Axel Benner, Michael Sabel, Peter Lichter, Guido Reifenberger, Andreas von Deimling, Christian Hartmann, DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas. Brain Pathology. ,vol. 17, pp. 363- 370 ,(2007) , 10.1111/J.1750-3639.2007.00083.X
Rudolf Jaenisch, Adrian Bird, Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nature Genetics. ,vol. 33, pp. 245- 254 ,(2003) , 10.1038/NG1089
J.CIark Susan, Janet Harrison, Cheryl L. Paul, Marianne Frommer, High sensitivity mapping of methylated cytosines. Nucleic Acids Research. ,vol. 22, pp. 2990- 2997 ,(1994) , 10.1093/NAR/22.15.2990
Mark Dizik, Judith K. Christman, Elsie Wainfan, Alterations in expression and methylation of specific gene in livers of rats fed a cancer promoting methyl-deficient diet Carcinogenesis. ,vol. 12, pp. 1307- 1312 ,(1991) , 10.1093/CARCIN/12.7.1307
Kristen H. Taylor, Robin S. Kramer, J. Wade Davis, Juyuan Guo, Deiter J. Duff, Dong Xu, Charles W. Caldwell, Huidong Shi, Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Cancer Research. ,vol. 67, pp. 8511- 8518 ,(2007) , 10.1158/0008-5472.CAN-07-1016
Aiala Lorente, Wolf Mueller, Edurne Urdangarín, Paula Lázcoz, Ulrike Lass, Andreas von Deimling, Javier S. Castresana, RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathology. ,vol. 19, pp. 279- 292 ,(2009) , 10.1111/J.1750-3639.2008.00185.X
Kyle D. Weaver, Stuart A. Grossman, James G. Herman, Methylated Tumor-Specific DNA as a Plasma Biomarker in Patients with Glioma Cancer Investigation. ,vol. 24, pp. 35- 40 ,(2006) , 10.1080/07357900500449546