Individualized texting for adherence building (iTAB): improving antiretroviral dose timing among HIV-infected persons with co-occurring bipolar disorder.

摘要: HIV+ persons with co-occurring bipolar disorder (HIV+/BD+) have elevated rates of medication nonadherence. We conducted a 30-day randomized controlled trial two-way, text messaging system, iTAB (n = 25), compared to an active comparison (CTRL) 25) improve antiretroviral (ARV) and psychotropic (PSY) adherence dose timing. Both groups received psychoeducation daily texts assessing mood. The group additionally personalized reminder texts. Participants responded over 90 % the mood messages. Mean adherence, as assessed via electronic monitoring caps, was high comparable between for both ARV (iTAB 86.2 vs. CTRL 84.8 %; p 0.95, Cliff's d 0.01) PSY 78.9 77.3 0.43, -0.13) medications. However, participants took ARVs significantly closer their intended dosing time than (iTAB: 27.8 CTRL: 77.0 min from target time; 0.02, 0.37). There no difference on Text interventions may represent low-burden approach improving timeliness medication-taking behaviors among difficult-to-treat populations. benefits improved timing long-term require additional investigation.