Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery.
作者： Michael B Mann , Nancy A Jenkins , Neal G Copeland , Karen M Mann
DOI: 10.1016/J.GDE.2013.11.004
关键词:
摘要: Sleeping Beauty (SB) is a powerful insertional mutagen used in somatic forward genetic screens to identify novel candidate cancer genes. In the past two years, SB has become widely adopted model human pancreatic, hepatocellular, colorectal and neurological cancers loci that participate tumor initiation, progression metastasis. Oncogenomic approaches have directly linked hundreds of genes identified by with cancers, many prognostic implications. These are aiding prioritize punitive for follow-up studies as possible biomarkers or therapeutic targets. This review highlights recent advances gene discovery, validate genes, efforts integrate data across all types drug development specificity.
sci-hub.se 参考文章(36)
Jesse D. Riordan, Vincent W. Keng, Barbara R. Tschida, Todd E. Scheetz, Jason B. Bell, Kelly M. Podetz-Pedersen, Catherine D. Moser, Neal G. Copeland, Nancy A. Jenkins, Lewis R. Roberts, David A. Largaespada, Adam J. Dupuy, Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis. PLOS Genetics. ,vol. 9, pp. 1- ,(2013) , 10.1371/JOURNAL.PGEN.1003441
Tracy L. Bergemann, Timothy K. Starr, Haoyu Yu, Michael Steinbach, Jesse Erdmann, Yun Chen, Robert T. Cormier, David A. Largaespada, Kevin A. T. Silverstein, New methods for finding common insertion sites and co-occurring common insertion sites in transposon- and virus-based genetic screens Nucleic Acids Research. ,vol. 40, pp. 3822- 3833 ,(2012) , 10.1093/NAR/GKR1295
Jeroen de Ridder, Anthony Uren, Jaap Kool, Marcel Reinders, Lodewyk Wessels, Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens PLOS Computational Biology. ,vol. 2, ,(2005) , 10.1371/JOURNAL.PCBI.0020166
K. A. O'Donnell, V. W. Keng, B. York, E. L. Reineke, D. Seo, D. Fan, K. A. T. Silverstein, C. T. Schrum, W. R. Xie, L. Mularoni, S. J. Wheelan, M. S. Torbenson, B. W. O'Malley, D. A. Largaespada, J. D. Boeke, A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 7966- 7967 ,(2012) , 10.1073/PNAS.1115433109
Louise van der Weyden, Mark J Arends, Alistair G Rust, George Poulogiannis, Rebecca E McIntyre, David J Adams, Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1 Molecular Cancer. ,vol. 11, pp. 29- 29 ,(2012) , 10.1186/1476-4598-11-29
H Nikki March, Alistair G Rust, Nicholas A Wright, Jelle ten Hoeve, Jeroen de Ridder, Matthew Eldridge, Louise van der Weyden, Anton Berns, Jules Gadiot, Anthony Uren, Richard Kemp, Mark J Arends, Lodewyk F A Wessels, Douglas J Winton, David J Adams, Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis Nature Genetics. ,vol. 43, pp. 1202- 1209 ,(2011) , 10.1038/NG.990
H. Koso, H. Takeda, C. C. K. Yew, J. M. Ward, N. Nariai, K. Ueno, M. Nagasaki, S. Watanabe, A. G. Rust, D. J. Adams, N. G. Copeland, N. A. Jenkins, Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 201215899- ,(2012) , 10.1073/PNAS.1215899109
J. Z. Tang, C. L. Carmichael, W. Shi, D. Metcalf, A. P. Ng, C. D. Hyland, N. A. Jenkins, N. G. Copeland, V. M. Howell, Z. J. Zhao, G. K. Smyth, B. T. Kile, W. S. Alexander, Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 110, pp. 6091- 6096 ,(2013) , 10.1073/PNAS.1304234110
S. Jones, X. Zhang, D. W. Parsons, J. C.-H. Lin, R. J. Leary, P. Angenendt, P. Mankoo, H. Carter, H. Kamiyama, A. Jimeno, S.-M. Hong, B. Fu, M.-T. Lin, E. S. Calhoun, M. Kamiyama, K. Walter, T. Nikolskaya, Y. Nikolsky, J. Hartigan, D. R. Smith, M. Hidalgo, S. D. Leach, A. P. Klein, E. M. Jaffee, M. Goggins, A. Maitra, C. Iacobuzio-Donahue, J. R. Eshleman, S. E. Kern, R. H. Hruban, R. Karchin, N. Papadopoulos, G. Parmigiani, B. Vogelstein, V. E. Velculescu, K. W. Kinzler, Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses Science. ,vol. 321, pp. 1801- 1806 ,(2008) , 10.1126/SCIENCE.1164368
Vincent W. Keng, Barbara J. Ryan, Kirk J. Wangensteen, Darius Balciunas, Christian Schmedt, Stephen C. Ekker, David A. Largaespada, Efficient transposition of Tol2 in the mouse germline. Genetics. ,vol. 183, pp. 1565- 1573 ,(2009) , 10.1534/GENETICS.109.100768