Uncoupling And Recoupling Of Autonomic Regulation Of The Heart Beat In Pediatric Septic Shock

摘要: Healthy physiological systems exhibit marked signal variability and complexity, whereas diseased generally show a loss of variability, decreased complexity ("decomplexification"), increased regularity. The goal this study was to evaluate the uncoupling recoupling phenomenon in children with septic shock by observing serial changes heart rate metrics. Data were collected from 7 using computer system Complex Systems Laboratory at Oregon Health Sciences University. Heart time series constructed analyzed Hales Research System intervals 6 h during pediatric intensive care unit (PICU) hospitalization. These power spectral values then plotted vs. time. Six seven patients showed an increase over low-frequency low-/high-frequency ratio, high-frequency decreased. We also compared change mean rate, standard deviation, first 24 PICU hospitalization remainder stay (for 5 length > 48 h). Compared initial PICU, ratio increased, course illness. This report shows potential value monitoring shock. Our results are agreement other investigators who evidence decomplexification both experimental models sepsis clinical studies provide direction for further work.