Structure of the multidrug resistance P-glycoprotein

摘要: Abstract In order to elucidate the mechanism by which multidrug resis tance P-glycoprotein extrudes cytotoxic drugs from cell, and particularly number nature of drug binding site(s), knowledge structure P-gp is essential. A considerable body genetic biochemical data has accrued gives insights into function. These are critically reviewed, in relation low resolution recently been determined electron microscopy. one best characterised ABC transporters these structure-function studies may have more general implications.