Significance of Adrenergic Stimuli for Cardiac Remodeling under Chronic Overload: Relative Importance of Myocardial Factors versus Ventricular Geometry in Cardiac Failure

摘要: It is generally accepted that, in addition to mechanical factors, humoral actions play a role the regulation of cardiac myocyte growth. The catecholamines were particularly regarded as “hypertrophy hormones” by some authors [1–12]. Furthermore, sympathetic nervous system seems pathogenesis congestive heart failure. Activation this with elevated plasma catecholamine level and corresponding consequences for peripheral resistance, energetics, adrenergic receptor density universal response impaired function [13–16]. A direct relation between mortality patients chronic failure has been demonstrated [3,16]. There be general agreement that application full β-agonists, while providing acute hemodynamic improvement, serious adverse effects long-term use. With regard β-adrenergic blockade, beneficial well detrimental have reported [17–22].