Local Slow Waves in Superficial Layers of Primary Cortical Areas during REM Sleep.

摘要: Sleep is traditionally constituted of two global behavioral states, non-rapid eye movement (NREM) and rapid (REM), characterized by quiescence reduced responsiveness to sensory stimuli [1]. NREM sleep distinguished slow waves spindles throughout the cerebral cortex REM an "activated," low-voltage fast electroencephalogram (EEG) paradoxically similar that wake, accompanied movements muscle atonia. However, recent evidence has shown cortical activity patterns during wake are not as previously thought. Local can appear in various regions both awake humans [2] rodents [3-5]. Intracranial recordings [6] [4, 7] have most often involve only a subset brain varies from wave rather than occurring near synchronously across all areas. Moreover, some areas transiently "wake up" [8] otherwise sleeping brain. Yet until now, was thought be homogenously wake-like. We show here, using local laminar freely moving mice, occur regularly sleep, but primary motor mostly layer 4, main target relay thalamic inputs, 3. This finding may help explain why, we remain disconnected environment even though bulk shows wake-like, paradoxical activation.