Reversal of cardiopulmonary exercise intolerance in patients with post-thrombotic obstruction of the inferior vena cava

摘要: Abstract Background It is unclear whether cardiopulmonary exercise intolerance in patients with chronic obstruction of the inferior vena cava (IVC) reversible following endovascular IVC reconstruction. Methods In 17 (mean age 45 ± 15 years, 71% men) post-thrombotic syndrome due to and preserved left ventricular ejection fraction 58 ± 3%), we performed testing before 3 months after reconstruction 4.1 ± 1.5 implanted stents). The median time from latest episode deep vein thrombosis intervention was 150 (interquartile range 102–820) days. Results At baseline, 12 (71%) reported New York Heart Association (NYHA) class II or III symptoms, 76% did not achieve >85% predicted oxygen uptake at peak 61.8 ± 13.7%). After reconstruction, changes were observed anaerobic threshold: work rate increased by 14.6 W, 95%CI (−0.7; 30.0), 1.8 ml/kg, (0.3; 3.3). Oxygen pulse 1.95 ml per beat, (1.12; 2.78), corresponding a mean relative increase 22.5%, (12.4; 32.7) (p  Conclusions obstruction, as result impaired cardiac filling least partially Study registration URL: https://clinicaltrials.gov . Unique identifier: NCT02433054