Nerve growth factor potentiates the neurotoxicity of beta amyloid.

摘要: Abstract The role of growth factors in the pathogenesis Alzheimer disease is unknown. The beta-amyloid protein accumulates abnormally brain and neurotoxic to differentiated hippocampal neurons culture. Nerve factor (NGF) increased potency a polypeptide by approximately 100,000, which resulted reduction EC50 from 0.1 microM 1 pM. This potentiating effect NGF was reversed monoclonal antibody against not observed for variety other neurotrophic factors. Exposure very low concentrations beta amyloid alone marked induction immunoreactive receptors. Addition with appearance neurodegenerative changes receptor-positive neurons. early profound degeneration basal forebrain cholinergic that occurs may result interaction NGF.