Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644
作者： J. M. Littleton , H. J. Little , M. A. Whittington
DOI: 10.1007/BF02244612
关键词:
摘要: The effects of dihydropyridine calcium channel antagonists, and the activator, Bay K 8644, were examined on convulsive behaviour induced by handling in mice following withdrawal from chronic ethanol inhalation. Nimodipine nitrendipine PN 200-110 significantly decreased behaviour, after intraperitoneal doses same order magnitude as have been found others to be required for displacement radiolabelled CNS. (+) isomer was effective, but (−) isomer, which is ineffective vitro, had no significant action. 8644 prevented actions nimodipine against syndrome. behavioural ratings plus higher than vehicle treatment. alone, when given naive mice, caused resembling that seen treatment, during did not increase signs.
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