Intravenous cocaine-induced place preference: attenuation by haloperidol
作者： Christina Spyraki , George G. Nomikos , Denis D. Varonos
DOI: 10.1016/0166-4328(87)90016-7
关键词:
摘要: Cocaine reward was demonstrated by establishing a conditioned place preference (CPP) to distinctive location paired with cocaine administered either intravenously (i.v., 0.5 mg/kg) or intraperitoneally (i.p., 10 mg/kg). Significant i.p. i.v. CPP observed following the second conditioning trial. Haloperidol (0.2 pretreatment disrupted induced i.v., but not i.p., cocaine. The haloperidol effect built up over successive trials. involvement of dopaminergic transmission in cocaine-induced is discussed.
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