What do we know about laminar connectivity

摘要: In this brief review, I attempt an overview of the main components anatomical laminar-level connectivity. These are: extrinsic outputs, excitatory and inhibitory intrinsic connectivity, inputs. Supporting data are biased from visual system nonhuman primates (NHPs), but have drawn as much possible a broader span in order to treat important issue area-specific variability. second part, briefly discuss laminar connectivity context network organization (feedforward/feedback cortical connections, major types corticothalamic connections). also point out issues need clarification, including more systematic, whole brain coverage tracer injections; on anterogradely labeled terminations; complete, quantitative about projection neurons, terminal density convergence. Postsynaptic targets largely unknown, their identification is essential for understanding finer analysis principles patterns. Laminar resolution MRI offers promising new tool exploring connectivity: it potentially fast macro-scale, allows repeated investigation under different stimulus conditions. Conversely, resolution, although detailed beyond current level visualization, rich trove experimental design interpretation fMRI activation