Controlling drug delivery kinetics from mesoporous titania thin films by pore size and surface energy

摘要: The osseointegration capacity of bone-anchoring implants can be improved by the use drugs that are administrated an inbuilt drug delivery system. However, to attain superior control and have ability administer varying size, including proteins, further material development carriers is needed. Mesoporous materials shown great potential in applications provide maintain a concentration within therapeutic window for desired period time. Moreover, from coatings consisting mesoporous titania has promising improve healing implants. Here we report on how osteoporosis drug, alendronate, controlled altering pore size surface energy thin films. was varied 3.4 nm 7.2 different structure-directing templates addition swelling agent. also altered grafting dimethylsilane walls. uptake release profiles were monitored situ using quartz crystal microbalance with dissipation (QCM-D) it both had profound effect adsorption kinetics alendronate. QCM-D data provided evidence films binding-diffusion mechanism. yielded knowledge crucial order vivo tissue response associated treatments.