Metabolic complications of severe malaria.

摘要: Metabolic complications of malaria are increasingly recognized as contributing to severe and fatal malaria. Disorders carbohydrate metabolism, including hypoglycaemia lactic acidosis, amongst the most important markers disease severity both in adults children infected with Plasmodium falciparum. Aminoacid lipid metabolism also altered by In adults, is associated increased glucose turnover quinine-induced hyperinsulinaemia, which causes peripheral uptake glucose. Hypoglycaemia results from a combination decreased production and/or glucose, due anaerobic glycolysis. Patients should be monitored frequently for treated rapidly intravenous if detected. The common aetiology hyperlactataemia probably caused generalized microvascular sequestration parasitized erythrocytes that reduces blood flow tissues. Several potential treatments have been investigated, but their effect on mortality has not determined.