Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors

摘要: The present invention relates to phosphodiesterase (PDE) type 4, 7 and dual PDE 4 /PDE inhibitors. Compounds disclosed herein having the structure of Formura 1: can be useful in treatment, prevention, inhibition or suppression CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting immune system, including AIDS, rejection transplant, auto-immune disorders T-cell related rheumatoid arthritis; inflammatory respiratory inflammation chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult distress syndrome (ARDS) other but not limited psoriasis, shock, atopic dermatitis, eosinophilic granuloma, conjunctivitis, osteoarthritis; gastrointestinal Crohn's disease, colitis, pancreatitis well different types cancers leukaemia; especially humans. Processes preparation compounds, pharmaceutical compositions containing compounds their use inhibitors are provided.