The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve.

摘要: Axonal transport in primate optic nerve axons was studied by autoradiography, scintillation counting, and electron microscopy under conditions of short-term intraocular pressure elevation. With elevation to 30 mm. Hg below mean arterial blood pressure, blockage detected within 2 hours autoradiography 1 hour microscopy. The earliest buildup radioactively labeled protein ultrastructurally visible cellular organelles the scleral lamina cribrosa. degree blockage, judged amount label buildup, increased with time. Some transported material traversed cribrosa despite at level tested. Reversal blockade occurred rapidly after normalization pressure.