Myostatin Decreases with Aerobic Exercise and Associates with Insulin Resistance

摘要: Purpose: There is mounting evidence that skeletal muscle produces and secretes biologically active proteins or "myokines" facilitate metabolic cross talk between organ systems. The increased expression of myostatin, a secreted anabolic inhibitor growth development, has been associated with obesity insulin resistance. Despite these intriguing findings, there have few studies linking myostatin resistance. Methods: To explore this relationship in more detail, we quantified protein plasma from 10 insulin-resistant, middle-aged (53.1 ± 5.5 yr) men before after 6 months moderate aerobic exercise training (1200 kcal·wk at 40%-55% V?O ). establish cause-effect relationship, also injected C57/Bl6 male mice high physiological levels recombinant protein. Results: Myostatin were shown to decrease (37%, = 0.042, 10) matching samples (from 28.7 ng·mL pretraining 22.8 ng·mL posttraining, 0.003, 9) exercise. Furthermore, the strong correlation sensitivity ( = 0.82, < 0.001, suggested was subsequently confirmed by inducing resistance myostatin-injected mice. A modest increase (44%) significant reductions insulin-stimulated phosphorylation Akt (Thr ) both liver myostatin-treated animals. Conclusions: These findings indicate are regulated and, furthermore, causal pathway acquired physical inactivity.