作者: Sean Ekins , Natalie Diaz , Julia Chung , Paul Mathews , Aaron McMurtray
DOI: 10.1007/S11095-016-2039-5
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摘要: How do we inspire new ideas that could lead to potential treatments for rare or neglected diseases, and allow serendipity help catalyze them? many potentially good are lost because they never tested? What if those have therapeutic approaches major healthcare advances? If a clinician anyone matter, has idea want test develop molecule translate the clinic, how would it without laboratory funding? These not idle theoretical questions but addressing them huge economic implications nations. fail capture diversity of may also lose out on next blockbuster treatments. Many involved in process ideation be discouraged simply know where go. We try address these describe there options raising funding, even small scale investments can foster preclinical clinical translation, several outsourcing experiments, whether collaborators commercial enterprises. While far from complete solutions, first steps taken by virtually while work other solutions build more concrete structure “idea—hypothesis testing—proof concept—translation—breakthrough pathway”.