Effects of configuration around the chiral carbon atoms on the crystal properties of ephedrinium and pseudoephedrinium salicylates.
作者： Sarma P. Duddu , David J. W. Grant
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摘要: The physicochemical properties and crystal structures of the crystalline salts formed by interaction an achiral anion, salicylate, with homochiral racemic ephedrinium pseudoephedrinium cations were determined. or salicylate in aqueous solution yielded notable exception ephedrinium. Evaporation solvent from solutions ephedrine salicyclic acid various organic solvents, as well grinding together solid salicylic acid, viscous semisolids suggesting that has a low melting point and/or high solubility. Mixing two solids, obtained each opposite enantiomers equimolar resulted formation subsequently, upon heating, salicylate. While exists compound (P21/n space group) equal number unit cell, its diastereomer, conglomerate, i.e. physical mixture, crystals (each P21 group). inability to exist salt at 20–25°C is attributed energy conformation poor packing molecules lattice.
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