Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates.
作者： Alejandro Colman-Lerner , Tina E. Chin , Roger Brent
DOI: 10.1016/S0092-8674(01)00596-7
关键词:
摘要: In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation localization of the Ace2 transcription factor daughter nucleus. Ectopic active mother nuclei sufficient activate genes in mothers. Eight are under tested conditions, while two only saturated cultures. Some gene products contribute cell separation degrading wall. These experiments define programs specific describe how those controlled.
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