Novel Enzymes for Biotransformation and Resolution of Alpha-Amino Acids
作者： Paul C. Engel , Francesca Paradisi
DOI: 10.1016/B978-008045382-8.00700-0
关键词:
摘要: This chapter reviews recent applications of enzymes in the production and transformation amino acids, both biological nonnatural. Applications chiral synthesis, kinetic resolution, interconversion enantiomers, oxoacids are all considered. The is categorized according to classes that have been employed: (1) acid oxidases, (2) dehydrogenases, (3) aminotransferases, (4) lipases, proteinases, N-acylases, (5) l-amino (6) hydantoinases carbamylases, (7) nitrilases, nitrile hydratases, amidases. It discusses various approaches leading discovery new/improved biocatalysts including screening types protein engineering, addresses some recurrent issues such as coenzyme recycling, also looks at examples whole-cell biocatalysis.
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