Chapter 15 – Endothelial Cells as Targets of the Intravascular Parasitic Disease Schistosomiasisa
作者： Claudia Lucia Martins Silva
DOI: 10.1016/B978-0-12-801078-5.00015-7
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摘要: Schistosomiasis is an intravascular human disease caused by the worm Schistosoma mansoni and characterized chronic inflammation morbidity. After skin invasion, migratory forms (schistosomula) travel through host’s cardiovascular system. Adult worms reside lay eggs while attached to vasculature, in direct contact with endothelial cells lining lumen of vessels. These control vascular tone, leukocyte trafficking, innate immunity, angiogenesis. Their function phenotype may vary depending on tissue residence, variations be epigenetically regulated. There mounting evidence that are important targets schistosomiasis, dysfunction several affected organs. This chapter highlights some consequences dysfunctions – such as increased adhesion, altered vasoconstriction, angiogenesis, fibrosis account for clinical manifestations schistosomiasis.
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