Pharmacologic Monitoring of Immunosuppressive Drugs

摘要: Organ transplantation as a treatment modality for patients with end-stage organ diseases of kidney, heart, liver, and pancreas has achieved impressive results in the past 2 decades thanks to better understanding basic immunobiology more advanced measures medical surgical management. Although immunosuppressive therapies overcome host reaction allografts have been employed since early days clinical transplantation, agents protocols are constantly evolving. Since 1978 introduction cyclosporine (CsA) [1] there some doubt about its value single most important agent armamentarium maintenance immunosuppression transplantation. Triple-drug therapy CsA, corticosteroid azathioprine is now frequently used regimen cadaver kidney recipients. However, continuing search selective specific become, decade, one priorities transplant medicine. Some these compounds entering routine practice: among them tacrolimus, mycophenolate mofetil (MMF) sirolimus.