Interaction of naproxen amphiphilic derivatives with biomembrane models evaluated by differential scanning calorimetry and Langmuir–Blodgett studies

摘要: Abstract Anti-inflammatory drugs represent a potential new strategy for the treatment of Alzheimer’s disease (AD). The ability to cross blood–brain barrier and reach brain tissues is critical point these strictly related their lipophilicity. Naproxen (NAP) non-steroidal anti-inflammatory drug (NSAIDs) under active investigation AD. To improve its lipophilic character, NAP was conjugated through diethylamine spacer (EDA) lipoamino acids (LAA), α-amino containing long alkyl side chain, obtain NAP–EDA–LAA10 NAP–EDA–LAA14 prodrugs. interaction prodrugs with dimyristoylphosphatidylcholine phospholipids, forming either multilamellar vesicles or monolayers (at air/water interface) used as biomembrane models, studied by differential scanning calorimetry Langmuir–Blodgett techniques. Experimental data showed that conjugation LAA residues able enhance such models.