Trypanosoma rangeli: un protozoo infectivo y no patógeno para el humano que contribuye al entendimiento de la transmisión vectorial y la infección por Trypanosoma cruzi, agente causal de la enfermedad de Chagas
作者： Gustavo Adolfo Vallejo , Jazmín Suárez , Jenny Lorena Olaya , Sneider Alexander Gutierrez , Julio César Carranza
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摘要: Unlike Trypanosoma cruzi, the causative agent of Chagas’ disease, T. rangeli is an infective, non-pathogenic parasite for humans, but pathogenic vectors from Rhodnius genus. Several genotypes (KP1+/A, B, KP1-/C, KP1-/D and E) have been described based on kinetoplast DNA (kDNA) polymorphisms, spliced leader or miniexon, intergenic transcribed spacer (ITS) small ribosomal subunit (SSUrRNA). These are selectively transmitted by two phylogenetic lines, thereby indicating co-evolutionary processes between vector genotypes. The Robustus line (Rhodnius prolixus, R. robustus neglectus) exclusively transmits KP1+/A genotype Pallescens (R. pallescens, colombiensis ecuadoriensis) only KP1-/C genotype. Even though little knowledge available regarding molecular basis parasitevector interaction, present work presents unpublished observations about ability to complete life-cycle some 19 species detection trypanolytic factors in neglectus against cruzi advances molecular, transcriptome genomic studies dealing with presented compared cruzi; these starting point understanding selective vectorial transmission pathogenicity vector, as well inability invade mammalian cells.
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