Toxoplasma gondii som orsak till beteendeförändringar hos människa
作者： Ylva Persson Leijer
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摘要: Toxoplasma gondii ar en obligat intracellular parasit med kattdjur som huvudvard och de flesta varmblodiga djur, inklusive manniska, mellanvard. I mellanvarden bildas vavnadscystor, framst i nerv- muskelceller, innehallande langsamt delande bradyzoiter. Smittan sprids framfor allt via foda kontaminerad oocystor fran kattens faeces, otillrackligt upphettat kott infektiosa vavnadscystor eller kongenital overforing. Infektionen livslang det har lange antagits att endast immunsupprimerade individer gravida kvinnor uppvisar allvarliga kliniska symptom. Studier visat beteendeforandringar hos infekterade immunkompetenta moss dock lett till forskning gallande eventuella manniska orsakade av T. gondii. Infektion associerats forandringar den kemiska sammansattningen hjarnan. celler okade nivaer dopamin samt ett, for dopamin, hastighetsbestammande enzym setts. Aven sankta tryptofan (vilket forsvarar overlevnad gondii) visats. En normal niva nodvandig syntesen serotonin laga kan saledes leda serotonin. Obalanserade kopplas schizofreni kopplats bl.a. depression aggression. Dessa mekanismer antas vara mojliga orsaker studier kunnat visa manniskor. Ett flertal ett samband mellan latent toxoplasmos, men aven kopplingar sjalvmord, sjalvskadebeteende, personlighetsforandringar, forsamrad reaktions- koncentrationsformaga Det senare bidragande orsak personer visats lopa hogre risk trafikolyckor. undersokts denna litteraturstudie visar anti-T. gondii-IgG d.v.s. kroniska formen toxoplasmos. flera graden beteendeforandringarna ocksa oka infektionens duration. Ett fatal antikroppstitrar, vilket forekommer tidigt infektionen om reaktiveras. anses mest sannolikt. Det mesta tyder pa association gondii-infektion beteendeforandringar, huruvida orsaken immunforsvaret parasiten sjalv annu inte klarlagt. sannolikt kombination dessa tva mer kravs klarlagga mekanismer. Utokad forhoppningsvis utveckling strategier behandling gondii-infektion.
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