Cytopathic Feline Leukemia Viruses Cause Apoptosis in Hemolymphatic Cells
作者： J. L. Rojko , J. R. Hartke , C. M. Cheney , A. J. Phipps , J. C. Neil
DOI: 10.1007/978-3-642-79850-4_2
关键词:
摘要: Certain isolates of the oncoretrovirus feline leukemia virus (FeLV) are strongly cytopathic for hemolymphatic cells. A major cytopathicity determinant is encoded by SU envelope glycoprotein gp70. Isolates with subgroup C gp70 genes specifically induce apoptosis in cells but not fibroblasts. In vitro exposure T-cells to FeLV-C leads first productive viral replication, next virus-induced cell agglutination, and lastly apogenesis. This phenomenon may explain severe progressive thymic atrophy erythroid aplasia which follow viremic infection vivo. Inappropriate induction has also been hypothesized thymicolymphoid immune deterioration associated FeLV containing variant genes. The influence hypervariability (variable regions 1 [Vr1] 5 [Vr5] on tropism, viremia induction, neutralizing antibody development discussed. potentially elements Vr5 derive from replication-defective, poorly expressed, endogenous FeLVs. Other more highly conserved TM p15E induction.
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