Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study.

摘要: Object. By pursuing a policy of very early aneurysm treatment in neurosurgical centers, in-hospital rebleeds can be virtually eliminated. Nonetheless, as many 15% patients with rupture suffer ultraearly rebleeding high mortality rates, and these individuals are beyond the reach even most ambitious protocol for diagnosis referral. Only drugs given immediately after subarachnoid hemorrhage (SAH) has been established at local hospital level can, theory, contribute to minimization such rebleeding. The object this randomized, prospective, multicenter study was assess efficacy short-term antifibrinolytic tranexamic acid preventing Methods. suffering SAH verified on computerized tomography (CT) scans within 48 hours prior first admission were included. A 1-g dose intravenously soon had hospi...