TRPC1 store-operated cationic channel subunit.

摘要: TRPC1 is a membrane protein that highly conserved in mammals, amphibians and birds. It widely expressed cells throughout the body including heart nervous system. Amino acid sequence analysis over-expression studies indicate it an ion channel allows transmembrane flux of small cations sodium calcium. In some cell types apparent at least fraction exists plasma membrane. Inhibition expression or block by TRPC1-specific antibody leads to attenuation calcium influx occurs response depletion levels sarcoplasmic endoplasmic reticulum. would, therefore, seem be key subunit store-operated channels (SOCs). is, nevertheless, unlikely act alone. There good evidence can heteromultimerise with related proteins TRPC4, TRPC5 polycystin-2; tetrameric arrangement envisaged, but not demonstrated. Like its relative Drosophila, looks likely function signalplex, complex inositol 1,4,5-triphosphate (IP(3)) receptor, calcium-ATPase, caveolin-1 calmodulin. Its localisation membranes punctate associated functionally discrete signals. TRPC1's may only linked SOCs also other cellular events nuclear translocation NFAT transcription factor. still much learned about this fundamental protein.