The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans.
作者： Stefan Blech , Thomas Ebner , Eva Ludwig-Schwellinger , Joachim Stangier , Willy Roth
关键词:
摘要: … and metabolism of the direct thrombin inhibitor dabigatran (BIBR … An orally active direct thrombin inhibitor would offer a … Dabigatran is a reversible, competitive, direct thrombin inhibitor …
sci-hub.se 参考文章(25)
Nicolaas G. M. Schipper, Thomas Österberg, Ulla Wrange, Carina Westberg, Anders Sokolowski, Roopa Rai, Wendy Young, Brita Sjöström, In vitro intestinal permeability of factor Xa inhibitors: influence of chemical structure on passive transport and susceptibility to efflux. Pharmaceutical Research. ,vol. 18, pp. 1735- 1741 ,(2001) , 10.1023/A:1013378731183
Conjugation-deconjugation reactions in drug metabolism and toxicity. Federation proceedings. ,vol. 46, pp. 2434- 2445 ,(1994) , 10.1007/978-3-642-78429-3
F P Guengerich, M V Martin, P H Beaune, P Kremers, T Wolff, D J Waxman, Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. Journal of Biological Chemistry. ,vol. 261, pp. 5051- 5060 ,(1986) , 10.1016/S0021-9258(19)89213-X
B. I. Eriksson, O. E. Dahl, L. Ahnfelt, P. Kälebo, J. Stangier, G. Nehmiz, K. Hermansson, V. Kohlbrenner, Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement: BISTRO I. Journal of Thrombosis and Haemostasis. ,vol. 2, pp. 1573- 1580 ,(2004) , 10.1111/J.1538-7836.2004.00890.X
Peter J. Wedlund, Grant R. Wilkinson, IN VIVO AND IN VITRO MEASUREMENT OF CYP2C19 ACTIVITY Methods in Enzymology. ,vol. 272, pp. 105- 114 ,(1996) , 10.1016/S0076-6879(96)72013-X
D. J. Newton, R. W. Wang, A. Y. H. Lu, Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes. Drug Metabolism and Disposition. ,vol. 23, pp. 154- 158 ,(1995)
J C Stevens, H Heyn, R B White, Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin. Drug Metabolism and Disposition. ,vol. 24, pp. 948- 954 ,(1996)
L C Quattrochi, J O Miners, R H Tukey, M E McManus, H V Gelboin, D J Birkett, M E Veronese, W Tassaneeyakul, Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. Journal of Pharmacology and Experimental Therapeutics. ,vol. 265, pp. 401- 407 ,(1993)
T. Shimada, H. Yamazaki, F. P. Guengerich, M. Mimura, Zuyu Guo, M. Persmark, K. Inoue, Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes. Molecular Pharmacology. ,vol. 46, pp. 568- 577 ,(1994)
Joachim Stangier, Hildegard Stähle, Karin Rathgen, Reinhold Fuhr, Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clinical Pharmacokinectics. ,vol. 47, pp. 47- 59 ,(2008) , 10.2165/00003088-200847010-00005