Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.
作者： Martin Richter , Solange Cloutier , Pierre Sirois
DOI: 10.1016/J.PLEFA.2007.02.004
关键词:
摘要: Abstract The role of endothelin, PAF and thromboxane A 2 in airway hyperreactivity (AHR) to carbachol induced by ovalbumin sensitization challenge Balb/c mice was investigated. Ovalbumin significant AHR actively sensitized challenged mice. Treatment these with the antagonist CV-3988 (10μgkg −1 , i.v.) completely abolished OVA-induced carbachol. TxA L-654,664 (1mgkg partially blocked induction OVA-challenged intranasal administration 50pmol ET receptor BQ-123 had no effect on PIP but produced a reduction at dose 100pmol. intravenous (100pmol) reduced only highest doses B BQ-788 administered either via or route Naive treated U-44069 (25 100μgkg i.v.), endothelin-1 (100pmol, intranasally) agonist IRL-1620 showed marked increase reactivity These results suggest an important for ovalbumin.
elsevier.com
sci-hub.se 参考文章(46)
C. G. Murlas, T. P. Murphy, V. Chodimella, O3-induced mucosa-linked airway muscle hyperresponsiveness in the guinea pig. Journal of Applied Physiology. ,vol. 69, pp. 7- 13 ,(1990) , 10.1152/JAPPL.1990.69.1.7
Frick O, Gold Wm, Chung Kf, Nadel Ja, Aizawa H, Becker Ab, Inhibition of antigen-induced airway hyperresponsiveness by a thromboxane synthetase inhibitor (OKY-046) in allergic dogs. The American review of respiratory disease. ,vol. 134, pp. 258- 261 ,(1986) , 10.1164/ARRD.1986.134.2.258
W M Abraham, J S Stevenson, R Garrido, A leukotriene and thromboxane inhibitor (Sch 37224) blocks antigen-induced immediate and late responses and airway hyperresponsiveness in allergic sheep. Journal of Pharmacology and Experimental Therapeutics. ,vol. 247, pp. 1004- 1011 ,(1988)
Heribert Konzett, Richard Rössler, Versuchsanordnung zu Untersuchungen an der Bronchiàlmuskulatur Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 195, pp. 71- 74 ,(1940) , 10.1007/BF01861842
B.A. Spicer, R.C. Baker, P.A. Hatt, S.M. Laycock, H. Smith, The effects of drugs on Sephadex-induced eosinophilia and lung hyper-responsiveness in the rat British Journal of Pharmacology. ,vol. 101, pp. 821- 828 ,(1990) , 10.1111/J.1476-5381.1990.TB14164.X
M Longphre, L Y Zhang, N Paquette, S R Kleeberger, PAF-induced airways hyperreactivity is modulated by mast cells in mice. American Journal of Respiratory Cell and Molecular Biology. ,vol. 14, pp. 461- 469 ,(1996) , 10.1165/AJRCMB.14.5.8624251
A Jörg, W R Henderson, R C Murphy, S J Klebanoff, Leukotriene generation by eosinophils. Journal of Experimental Medicine. ,vol. 155, pp. 390- 402 ,(1982) , 10.1084/JEM.155.2.390
János G. Filep, Martin G. Sirois, Anne Rousseau, Alain Fournier, Pierre Sirois, Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor. British Journal of Pharmacology. ,vol. 104, pp. 797- 804 ,(1991) , 10.1111/J.1476-5381.1991.TB12509.X
T.T. Kung, H. Jones, G.K. Adams, III, S.P. Umland, W. Kreutner, R.W. Egan, R.W. Chapman, A.S. Watnick, Characterization of a Murine Model of Allergic Pulmonary Inflammation International Archives of Allergy and Immunology. ,vol. 105, pp. 83- 90 ,(1994) , 10.1159/000236807
Michelle M. Epstein, Do mouse models of allergic asthma mimic clinical disease International Archives of Allergy and Immunology. ,vol. 133, pp. 84- 100 ,(2004) , 10.1159/000076131