FURTHER STUDIES ON THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND11

摘要: IN AN EARLIER STUDY 106 compounds were tested in rats for their capacity to interferewith the endocrine function of thyroid gland. Each substance was administered young bymixing it withthe food or drinking water various concentrations. At end ten days glands examined grossly and microscopically evidence hypertrophy hyperplasia,and relative activities then roughly compared on basis minimal dose required produce a noticeable effect (Astwood, 1943). Although this assay method sufficiently reliable detect wide differences activity form selection such as thiouracil clinical trial, suffered handicap subjective criteria no quantitative dosage-response relationship could be established. A more accurate reproducible based upon weight iodine concentration gland (Astwood & Bissell,1944) has been used present investigation.