Investigation of the swelling behaviour of hydrogels in aqueous acid or alkaline solutions
作者： Daniel Althans , Sabine Enders
DOI: 10.1080/00268976.2014.902517
关键词:
摘要: For development of tailor made drug delivery systems using poly(N-isopropylacrylamide) hydrogels, the influence acids and bases added to aqueous solution on swelling behaviour as function concentration, temperature kind acid or base were investigated experimentally. The selected are formic, acetic, propionic, lactic, succinic, α-ketoglutaric citric acid. applied sodium potassium hydroxide. was characterised by degree uptake hydrogel in swollen state. In case weak properties well phase transition concentration depends type acids, whereas shrunken state do not depend used. strong bases, ionic strength, but applied.
harvard.edu
sci-hub.se 参考文章(53)
L. P. N. Rebelo, Z. P. Visak, H. C. de Sousa, J. Szydlowski, R. Gomes de Azevedo, A. M. Ramos, V. Najdanovic-Visak, M. Nunes da Ponte, J. Klein, Double critical phenomena in (water + polyacrylamides) solutions Macromolecules. ,vol. 35, pp. 1887- 1895 ,(2002) , 10.1021/MA011533A
Howard G. Schild, David A. Tirrell, Microcalorimetric detection of lower critical solution temperatures in aqueous polymer solutions The Journal of Physical Chemistry. ,vol. 94, pp. 4352- 4356 ,(1990) , 10.1021/J100373A088
Allan S. Huffman, Ali Afrassiabi, Liang Chang Dong, Thermally reversible hydrogels: II. Delivery and selective removal of substances from aqueous solutions Journal of Controlled Release. ,vol. 4, pp. 213- 222 ,(1986) , 10.1016/0168-3659(86)90005-2
Xiangchun Yin, Allan S. Hoffman, Patrick S. Stayton, Poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers that respond sharply to temperature and pH. Biomacromolecules. ,vol. 7, pp. 1381- 1385 ,(2006) , 10.1021/BM0507812
Nikolaos A. Peppas, Atul R. Khare, PREPARATION, STRUCTURE AND DIFFUSIONAL BEHAVIOR OF HYDROGELS IN CONTROLLED RELEASE Advanced Drug Delivery Reviews. ,vol. 11, pp. 1- 35 ,(1993) , 10.1016/0169-409X(93)90025-Y
Joseph Kost, Robert Langer, Responsive polymer systems for controlled delivery of therapeutics Trends in Biotechnology. ,vol. 10, pp. 127- 131 ,(1992) , 10.1016/0167-7799(92)90194-Z
Ho-Mu Lin, Hsin-Yi Tien, Ying-Tzu Hone, Ming-Jer Lee, Solubility of selected dibasic carboxylic acids in water, in ionic liquid of (Bmim)(BF4), and in aqueous (Bmim)(BF4) solutions Fluid Phase Equilibria. ,vol. 253, pp. 130- 136 ,(2007) , 10.1016/J.FLUID.2007.02.011
Jie Zhang, Liang-Yin Chu, Yuan-Ke Li, Young Moo Lee, Dual thermo- and pH-sensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with rapid response behaviors Polymer. ,vol. 48, pp. 1718- 1728 ,(2007) , 10.1016/J.POLYMER.2007.01.055
M. Heskins, J. E. Guillet, Solution Properties of Poly(N-isopropylacrylamide) Journal of Macromolecular Science, Part A. ,vol. 2, pp. 1441- 1455 ,(1968) , 10.1080/10601326808051910
Melina Kalagasidis Krušić, Jovanka Filipović, Copolymer hydrogels based on N-isopropylacrylamide and itaconic acid Polymer. ,vol. 47, pp. 148- 155 ,(2006) , 10.1016/J.POLYMER.2005.11.002