Radical-promoted site-specific cross dehydrogenative coupling of heterocycles with nitriles.
作者： Zhong-Quan Liu , Zejiang Li
DOI: 10.1039/C6CC08213K
关键词:
摘要: A first free-radical triggered site-specific cross dehydrogenative coupling reaction of heterocycles with simple nitriles is developed. It allows efficient and facile access to various C-2 cyanoalkylated furans, thiophenes, indoles, pyrroles. The extremely high selectivities in this case indicate that functionalization an inert C-H bond could be well-controlled by radical initiation.
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